Masteron Enanthate

Indication: Masteron Enanthate is indicated for the treatment of breast cancer in elderly postmenopausal women as part of specific immunotherapy.

Description: Masteron Enanthate, known scientifically as Drostanolone Enanthate, is a dihydrotestosterone (DHT)-derived anabolic steroid. It is an ester prodrug of drostanolone, meaning that it is metabolized in the body to produce the active hormone drostanolone. This hormone has been structurally modified with a methyl group at the carbon 2 position, protecting it from metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme found in skeletal muscle and significantly enhancing its anabolic properties. The Enanthate ester controls the hormone’s release time, making it a preferred choice for therapeutic and non-medical uses.

Historical Background: Drostanolone, or dromostanolone, is an anabolic–androgenic steroid (AAS) of the DHT group, though it was never marketed in its raw form. Drostanolone Enanthate, however, has been used in the treatment of breast cancer under various brand names such as Drolban, Masteril, and Masteron. Additionally, it is utilized non-medically for physique- and performance-enhancing purposes. While Drostanolone Propionate is more common, Drostanolone Enanthate is available in some underground labs and does not require as frequent injections.

Mechanism of Action: Masteron Enanthate is well-known for its strong anti-estrogenic properties. It carries no estrogenic activity and can act as an anti-estrogen in the body, which has made it effective in breast cancer treatment. The combination of Masteron and Nolvadex (Tamoxifen Citrate) has been shown to be more effective than chemotherapy in treating inoperable breast cancer in postmenopausal women. Its lower androgenic rating compared to testosterone means a reduced risk of virilization, making it a more favorable option for women.

Medical Uses: The principal clinical indication of Drostanolone Enanthate in the United States and international markets is for the treatment of advanced inoperable breast cancer in women. It is particularly effective for tumors associated with hormone-active tissues like breast cancer. Estrogen receptor-positive (ER+) breast cancer cells use estrogen for growth, so antiestrogenic drugs like Drostanolone Enanthate are crucial for limiting tumor spread and size.

• Hormonal Therapy: Part of complex therapy for hormone-active tumors, particularly ER+ breast cancer.
• Anti-estrogenic Properties: Blocks estrogen receptors or decreases their expression, limiting tumor growth.
• Reduced Virilization Risk: Lower androgenic effects compared to testosterone, making it suitable for women.
• Palliative Care: Used for breast tumors unresponsive to other treatments or as palliative care for advanced, incurable tumors.

Considerations: The effects of Masteron Enanthate depend on the dose and period of administration. Higher doses and prolonged use increase the risk of virilization. However, its benefits in treating specific types of breast cancer and its application in performance enhancement, particularly during cutting phases, make it a valuable tool in both medical and athletic contexts.