Melanotan II

PRESENTATION

• 5 x 10 mg lyophilized powder vials

• 5 x 2 ml bacteriostatic water vials (for reconstitution)

ACTIVE INGREDIENT

Each vial contains:

• Melanotan II (Alpha-Melanocyte-Stimulating Hormone) 10 mg

DESCRIPTION

Melanotan II is a synthetic analog of the alpha-melanocyte-stimulating hormone (α-MSH), which plays a role in stimulating melanogenesis, the process that leads to skin pigmentation (tanning). It binds to melanocortin receptors in skin cells, encouraging melanin production, which enhances the body’s response to ultraviolet (UV) radiation by producing a tan. It has also been studied for its potential effects on sexual function and appetite suppression.

The product is supplied as a sterile, lyophilized powder to be reconstituted prior to administration.

PHARMACOLOGICAL CLASSIFICATION

Melanocortin Receptor Agonist

PHARMACOLOGICAL PROPERTIES

Mechanism of Action: Melanotan II binds to melanocortin receptors in melanocytes (skin cells), stimulating melanin production, which leads to a darker skin tone and protection from UV radiation. Additionally, it has secondary effects on appetite suppression and libido enhancement due to its interaction with melanocortin receptors in the brain.

Pharmacokinetics:

• Absorption: Rapidly absorbed after subcutaneous injection.
• Distribution: Distributed throughout the body, with effects primarily in the skin and brain.
• Metabolism: Metabolized in the liver.
• Excretion: Excreted through urine.

INDICATIONS

Melanotan II is indicated for:

Tanning: For individuals seeking to increase skin pigmentation to achieve a tanned appearance without excessive exposure to UV radiation.

UV Protection: May help protect skin from sun damage by promoting melanin production.

Potential Therapeutic Use: Under research for potential effects on sexual dysfunction and appetite control.

DOSAGE AND ADMINISTRATION

Dosage:

• Standard Dosing: Inject 0.25 mg to 1 mg subcutaneously once daily until the desired level of tanning is achieved. Maintenance doses may be taken intermittently as needed.
• Initial Test Dose: Start with a lower dose (0.25 mg) to assess individual tolerance, especially for users prone to side effects like nausea or flushing.

Administration:

1. Reconstitute the lyophilized powder with bacteriostatic water.
2. Inject subcutaneously into fatty tissue, such as the abdominal area.
3. Rotate injection sites to avoid localized irritation.

Reconstitution:

• Reconstitute the vial with 1 to 2 ml of bacteriostatic water.
• Store the reconstituted solution in the refrigerator and use within 14 days.

CONTRAINDICATIONS

• Hypersensitivity: Contraindicated in individuals with known hypersensitivity to Melanotan II or any of its components.
• Melanoma or Skin Cancer: Should not be used by individuals with a history of melanoma or other skin cancers, as the stimulation of melanocytes may pose a risk.

WARNINGS AND PRECAUTIONS

1. Risk of Darkened Moles or Skin Lesions: Melanotan II may cause the darkening of moles, freckles, and skin lesions. Patients should monitor any changes in skin appearance and consult a healthcare provider if necessary.

2. Nausea and Vomiting: Melanotan II may cause nausea, vomiting, or flushing, especially during the initial doses. It is recommended to start with a lower dose to assess tolerance.

3. Blood Pressure and Heart Rate Changes: In some individuals, Melanotan II may cause a temporary increase in blood pressure or changes in heart rate.

ADVERSE REACTIONS

Common side effects:

• Nausea or vomiting
• Flushing
• Increased skin pigmentation (in localized areas or across the body)
• Darkening of moles, freckles, or existing skin lesions
• Increased libido

Serious adverse effects:

• Hyperpigmentation: Overuse may lead to excessive darkening of the skin, especially in areas exposed to the sun.
• Skin Cancer Risk: Prolonged use or misuse may increase the risk of skin cancers due to overactive melanocyte stimulation.
• Allergic Reactions: Rare, but any allergic symptoms like swelling, difficulty breathing, or hives should be addressed immediately.

INTERACTIONS

• UV Protection Products: Use of sunscreen or other UV-blocking products is recommended, as Melanotan II does not replace the need for sun protection.
• Medications for Blood Pressure: If the patient is on medications for blood pressure, Melanotan II may cause temporary changes in blood pressure and should be monitored closely.

USE IN SPECIFIC POPULATIONS

Pregnancy and Lactation: The safety of Melanotan II during pregnancy or lactation has not been established. Its use is not recommended in these populations.

Pediatric Use: Melanotan II is not intended for use in children or adolescents under 18 years of age.

Geriatric Use: Older adults should use Melanotan II with caution due to the potential for side effects related to blood pressure and skin changes.

OVERDOSAGE

In case of overdose, symptoms may include severe nausea, vomiting, dizziness, and excessive skin darkening. Discontinue use and seek medical advice if overdose occurs.

STORAGE

• Store the lyophilized powder at room temperature (20°C to 25°C / 68°F to 77°F).
• After reconstitution, store the solution in a refrigerator at 2°C to 8°C (36°F to 46°F) and use within 14 days.
• Protect from light and do not freeze.
• Keep out of reach of children.

PACKAGING

Melanotan II is supplied in the following packaging:

• 5 x 10 mg vials of lyophilized powder
• 5 x 2 ml vials of bacteriostatic water

MANUFACTURER

Oxydine Metabolics Switzerland

Oxydine.org
Hi@Oxydine.org